L-Carnosine is a dipeptide made of Beta-Alanine and Histidine.
Carnosine is sometimes called the longevity molecule because it prevents AGE (Advanced Glycation Endproducts) and oxidative damage.
AGE is associated with damage from sugars bonding to proteins.
AGE is a major factor in cataract formation and diabetic retinopathy as well as degeneration of the kidneys, the nervous system and the cardiovascular system.
Unlike free form Carnosine, N-Acetyl Carnosine can enter the eye from the tear film because it is soluble in both aqueous compartments and lipid membranes.
Once inside the eye, N-Acetyl Carnosine is metabolized to L-Carnosine.
N-Acetyl Carnosine eye drops were first developed by Dr. Babizhayev at the Moscow Helmholtz Research Institute for Eye Diseases.
Placebo-controlled clinical trials with mild to advanced cataract showed improved visual acuity in 90% of subjects after 6 months.
Glare was also reduced for 89% of subjects.
No treated eyes became worse during the 2 year study.
The types of cataracts that improved included cortical, posterior subcapsular (PSC), nuclear and mixed types.
N-acetylcarnosine (NAC) drops for age-related cataract
Efficacy of N-acetylcarnosine in the treatment of cataracts